- Exit 257 - US 11, VA 259, to Broadway
- Exit 262mm - Rest Area both lanes, full handicap facilities, phone, vending, picnic tables, trash cans, pet area
- Exit 264 - US 211, New Market
- Exit 269 - RD 730, to Shenandoah Caverns
- Exit 273 - VA 292, RD 703, Mt Jackson
- Exit 277 - VA 614, Bowmans Crossing No Services
- Exit 279 - VA 185, RD 675, Edinburg
- Exit 283 - VA 42, Woodstock
- Exit 291 - RD 651, Toms Brook
- Exit 296 - US 48, VA 55, Strasburg
- Exit 298 - US 11, Strasburg
- Exit 300 - I-66 E, to Washington, Shenandoah NP, Skyline Dr No Services
- Exit 302 - RD 627, Middletown
- Exit 304mm - weigh station both lanes
- Exit 307 - VA 277, Stephens City
- Exit 310 - VA 37, to US 50W
- Exit 313 - US 17/50/522, Winchester
- Exit 315 - VA 7, Winchester
- Exit 317 - US 11, Stephenson
- Exit 320 - Welcome Center southbound, full handicap facilities, phone, vending, picnic tables, trash cans, pet area
- Exit 321 - RD 672, Clearbrook
- Exit 323 - RD 669, to US 11, Whitehall
- Exit 324mm - Virginia/West Virginia state line
