The arrests come after an investigation by the Bedford County Sheriff's Office at a Bedford motel.
25-year-old Jennifer Shepherd and 62-year-old Donald Fountain of Roanoke were arrested Jan. 27.
Shepherd has been charged with solicitation of prostitution and two charges of possession of schedule one drugs (cocaine and prescription drugs).
She was bonded from jail Jan. 29.
Fountain been charged with felony possession of cocaine, a felony charge of profiting from prostitution, and aiding prostitution.
He was bonded from jail on Feb. 5.