Devin Thomas had 20 points and a career-high 17 rebounds, and Wake Forest routed VMI 98-71 on Tuesday night.
Fellow sophomore Codi Miller-McIntyre added a career-high 23 points and has scored 20 in both games this season.
They helped Wake Forest (2-0) open with consecutive wins for the second time in coach Jeff Bzdelik's four years.
Travis McKie and Tyler Cavanaugh each scored 11 for the Demon Deacons.
They led by 30, shot 53 percent, outrebounded VMI 57-37 and outscored the Keydets in the paint 58-18.
Freshman QJ Peterson had 16 points, Rodney Glasgow scored 15 and D.J. Covington had 13 for VMI (2-1).
The Keydets, who haven't beaten Wake Forest since 1941, didn't get closer than 11 in the second half and were held to 29 percent shooting. In their two wins, they shot 40 percent.